D could facilitate improvement of efficient targeted therapies for oral cancer.Text S5 Detailed list of hypotheses with corresponding downstream causally related genes. File consists of following columns: (i) Causal Hypothesis/Gene NameRName in the gene which has been identified as considerable hypothesis by causal reasoning evaluation; (ii) RegulationRRelationship involving hypothesis gene and downstream gene, `+’ represents activation and `2′ represents inhibition; (iii) Downstream Gene(s)RDownstream gene(s) whose differential expression is predicted by hypothesis gene; (iv) PredictionR`C’ represents properly predicted connection in between hypothesis and downstream gene, whereas `I’ represents otherwise. The succeeding +/2 sign represents up2/ down-regulation resp., of the downstream gene(s); (v) SourceRThe name of Kegg pathway(s) utilised to infer causal connection amongst hypothesis connected downstream gene(s). (DOCX) Text S6 Processed list of hypotheses and downstream genes. File includes following columns: (i) Causal Hypothesis/ Gene NameRName of the gene which has been identified as substantial hypothesis by causal reasoning analysis; (ii) Diff_ExpRThe hypothesis genes which are differentially expressed in our evaluation are marked as `DE’ and non-differentially expressed hypothesis genes are marked as `N’; (iii) RegulationRRelationship between hypothesis gene and downstream gene, `+’ represents activation and `2′ represents inhibition; (iv) Downstream Gene(s) RDownstream gene(s) whose differential expression is predicted by hypothesis gene; (v) PredictionR`C’ represents appropriately predicted connection amongst hypothesis and downstream gene, whereas `I’ represents otherwise. The succeeding +/2 sign represents up2/down-regulation resp., on the downstream gene(s); (vi) SourceRThe name of Kegg pathway(s) applied to infer causal relationship amongst hypothesis related downstream gene(s). (DOCX) Text S7 Connectivity information and facts of genes in Causal Network. File includes connectivity info of gene(s) in causal network generated around the basis of causal relationships described in Text S5. It contains following columns: (i) SymbolRNCBI gene symbol of a constituting node or gene of the causal network; (ii) ConnectivityRTotal no. on the neighboring directly connected genes based on causal partnership.Formula of 4,6-Dichloropyridine-2,3-diamine (DOCX) Text S8 Text mining benefits of effectively annotated genes. This is a compressed file, which consist of the text mining final results of effectively annotated genes by our technique (offered as ,genesymbol.204715-91-3 Order _pub.PMID:23381626 txt files specific to a certain gene). *_pub.txt file consists of information about relevant articles applied for annotation of concerned gene. It includes following columns: (i) PubmedIDRPubmed ID with the short article; (ii) MarkerRBinary flag where `0′ implies that article doesn’t mention that concerned gene is often utilised as a marker, and `1′ implies that post supports the inference that concerned gene could be utilised as a marker; (iii) MarkerTypeRComma delimited field, which represent marker variety(s) described for the gene inside the short article; (iv) CancerHallmarkRBinary flag where `0′ implies that post will not mention that concerned gene is connected with cancer hallmarks, `1′ implies that short article supports the inference that concerned gene is associated with cancer hallmarks; (v) HallmarkTypeRComma delimited field, which represent cancer hallmarks(s) pointed out for the gene in the write-up; (vi) RelevantSentenceRList of relevant sentence(s) in the arti.